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Showing 1–4 of 4 results
Advanced filters: Author: Angela Pizzolla Clear advanced filters

  • Group 2 innate lymphoid cells (ILC2s) are generally considered to have pro-tumor functions. However, Belz and colleagues demonstrate that ILC2s have anti-melanoma effects due to their high production of the inflammatory cytokine granulocyte-macrophage colony-stimulating factor in the tumor microenvironment.

    • Nicolas Jacquelot
    • Cyril Seillet
    • Gabrielle T. Belz
    Research
    Nature Immunology
    Volume: 22, P: 851-864

  • Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.

    • Emma V. Petley
    • Hui-Fern Koay
    • Phillip K. Darcy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Spatial proteomic data serve to provide cell-level location information for the extraction of biological features from tissues, but analyzing such data can be difficult. Here the authors report the development of SPIAT for data analyses and spaSim for simulation and validation of methods to help bridge the gap between the technology and its translation.

    • Yuzhou Feng
    • Tianpei Yang
    • Anna S. Trigos
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20