Herpes simplex virus 2-infected individuals are shown to have skin-tissue-resident CD8αα+ T cells that persist at the portal of virus release in genital skin and mucosa, possess oligoclonal T-cell-receptor-β CDR3 sequences that are stable over time, and express gene signatures of antiviral and cytolytic function indicative of viral-specific immune surveillance.
- Jia Zhu
- Tao Peng
- Lawrence Corey
