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Showing 1–2 of 2 results
Advanced filters: Author: Angelika G. Aleman Clear advanced filters

  • Craniofacial malformations have been linked to congenital heart defects, as in 22q11.2 deletion syndrome, but the mechanisms linking these lineages remain unknown. Here they show that zebrafish nxk2.7 is expressed in cardiopharyngeal progenitors and has roles in craniofacial development that cannot be compensated for by nkx2.5.

    • Caitlin Ford
    • Carmen de Sena-Tomás
    • Kimara L. Targoff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Cardiac developmental genes have been associated with regenerative potential. Here the authors identify a Nkx2.5-dependent gene regulatory network operating through ect2, psmb3, and psmd7 to orchestrate cell cycle re-entry, proteolysis, and mitochondrial metabolism during myocardial repair.

    • Carmen de Sena-Tomás
    • Angelika G. Aleman
    • Kimara L. Targoff
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16