Microglia are involved in synaptic pruning during development. Here the authors show that mice deficient in the fractalkine receptor Cx3cr1, which show a transient reduction in microglia, have reduced synaptic multiplicity in the hippocampus, decreased functional connectivity between the prefrontal cortex and hippocampus and altered social and repetitive behaviors.
- Yang Zhan
- Rosa C Paolicelli
- Cornelius T Gross
