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Showing 1–2 of 2 results
Advanced filters: Author: Angie Kirchner Clear advanced filters

  • Direct conversion of 5-fdC into dC by C–C bond breakage is revealed by metabolic tracing studies through incorporation of synthetic stable isotope- and (R)-2′-fluorine-labeled dC and fdC derivatives into the genome of cultured mammalian cells.

    • Katharina Iwan
    • René Rahimoff
    • Thomas Carell
    Research
    Nature Chemical Biology
    Volume: 14, P: 72-78

  • The combination of heavy isotope labeling and ultra-high-pressure liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC–MS) is used to quantify modified genomic cytosines in pluripotent stem cells in different states and reveals active turnover of methylcytidine in oxidation-dependent and oxidation-independent manners.

    • Fabio Spada
    • Sarah Schiffers
    • Thomas Carell
    Research
    Nature Chemical Biology
    Volume: 16, P: 1411-1419