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Showing 1–7 of 7 results

Advanced filters: Author: Anindya Bagchi Clear advanced filters

PVT1 dependence in cancer with MYC copy-number increase

Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis.

Yuen-Yi Tseng
Branden S. Moriarity
Anindya Bagchi
Research22 Jun 2014
Nature

Volume: 512, P: 82-86
ecDNA hubs drive cooperative intermolecular oncogene expression

Extrachromosomal DNA (ecDNA) congregates in clusters called ecDNA hubs that promote intermolecular interactions between gene-regulatory regions and thereby amplify the expression of oncogenes such as MYC in cancer cell lines.

King L. Hung
Kathryn E. Yost
Howard Y. Chang
Research24 Nov 2021
Nature

Volume: 600, P: 731-736
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Circular extrachromosomal DNA in high-risk medulloblastoma contributes to tumor heterogeneity and associates with relapse and survival. Enhancer rewiring events involving known oncogenes are frequent events, affecting transcription and proliferation.

Owen S. Chapman
Jens Luebeck
Lukas Chavez
ResearchOpen Access09 Nov 2023
Nature Genetics

Volume: 55, P: 2189-2199
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

Kimberly L Stark
Bin Xu
Joseph A Gogos
Research11 May 2008
Nature Genetics

Volume: 40, P: 751-760
A multifaceted examination of the action of PDE4 inhibitor rolipram on MMP2/9 reveals therapeutic implications

Arka Bagchi
Analabha Roy
Arunima Biswas
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

The Polycomb group protein EZH2 promotes trimethylation of histone H3K27 and gene silencing. Cdk1 and Cdk2 are found to phosphorylate EZH2 and to positively regulate EZH2-mediated effects on global gene silencing, proliferation and migration.

Shuai Chen
Laura R. Bohrer
Haojie Huang
Research10 Oct 2010
Nature Cell Biology

Volume: 12, P: 1108-1114
Transcriptomic analysis of gene signatures associated with sickle pain

Jinny A. Paul
Anupam Aich
Kalpna Gupta
ResearchOpen Access16 May 2017
Scientific Data

Volume: 4, P: 1-9