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Showing 1–2 of 2 results
Advanced filters: Author: Anisah Adeagbo Clear advanced filters

  • Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted cancers and microsatellite-unstable cancers harbouring specific mutations.

    • Patricia C. Borck
    • Isabella Boyle
    • Francisca Vazquez
    ResearchOpen Access
    Nature
    Volume: 638, P: 1104-1111

  • Primary human hepatocyte (PHH) transplantation could be an alternative to liver transplantation. Here, the authors use the mRNA-LNP platform to express growth factors in the liver in a controlled manner to drastically improve PHH engraftment, thus, reducing disease burden and enhancing overall liver function.

    • Anna R. Smith
    • Fatima Rizvi
    • Valerie Gouon-Evans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12