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Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice

The role of Ifi27l2a, an interferon-induced gene, remains poorly understood in diseased brains. Here, authors show age and stroke-dependent upregulation of Ifi27l2a in microglia, and that reduction of Ifi27l2a leads to reduced brain injury and functional deficits after ischemic stroke.

Gab Seok Kim
Elisabeth Harmon
Sean P. Marrelli
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Benefits of equilibrium between microbiota- and host-derived ligands of the aryl hydrocarbon receptor after stroke in aged male mice

Peesh et al. show that ischemic stroke reduces microbiota-derived and increases host-derived aryl (AHR) hydrocarbon ligands. Post-stroke treatment with indole-based AHR ligands improved microglia-mediated antigen processing and co-stimulatory immune functions.

Pedram Peesh
Maria P. Blasco-Conesa
Bhanu Priya Ganesh
ResearchOpen Access19 Feb 2025
Nature Communications

Volume: 16, P: 1-16
A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections

An antibiotic identified via molecular-docking simulations and screening, and loaded into a bone-cement matrix, performs better than currently used antibiotic-loaded bone cements in the treatment of staphylococcal bone infections in rats.

Sumana Ghosh
Mau Sinha
Shiladitya Sengupta
Research13 Oct 2022
Nature Biomedical Engineering

Volume: 6, P: 1180-1195
Barriers at various levels of human ecosystem for maintaining adherence to gluten free diet in adult patients with celiac disease

Wajiha Mehtab
Ashish Agarwal
Govind Makharia
Research12 Jan 2024
European Journal of Clinical Nutrition

Volume: 78, P: 320-327
Efficacy of engineered GO Amberlite XAD-16 picolylamine sorbent for the trace determination of Pb (II) and Cu (II) in fishes by solid phase extraction column coupled with inductively coupled plasma optical emission spectrometry

Hina Javed
Aminul Islam
Sushil Kumar
ResearchOpen Access03 Dec 2018
Scientific Reports

Volume: 8, P: 1-11

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Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice

Benefits of equilibrium between microbiota- and host-derived ligands of the aryl hydrocarbon receptor after stroke in aged male mice

A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections

Barriers at various levels of human ecosystem for maintaining adherence to gluten free diet in adult patients with celiac disease

Efficacy of engineered GO Amberlite XAD-16 picolylamine sorbent for the trace determination of Pb (II) and Cu (II) in fishes by solid phase extraction column coupled with inductively coupled plasma optical emission spectrometry

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