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Showing 1–3 of 3 results
Advanced filters: Author: Anlu Chen Clear advanced filters

  • Whole-genome recoding has been shown to enable nonstandard amino acids, biocontainment and viral resistance in bacteria. Here the authors extend this to human cells using base editing to convert TAG to TAA for 33 essential genes via a single transfection followed by examining base-editing genome-wide.

    • Yuting Chen
    • Eriona Hysolli
    • George Church
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • PELO–HBS1L and SKI complexes in the human mRNA quality control pathway exhibit a synthetic lethal interaction and may represent novel targets for the development of cancer therapies.

    • Vivian Prindle
    • Adam E. Richardson
    • Joshua P. Plotnik
    ResearchOpen Access
    Nature
    Volume: 638, P: 1095-1103