Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Ann Boija Clear advanced filters

  • A vast landscape of ‘undruggable’ cancer targets remains beyond the reach of conventional therapeutic agents. Recent advances in artificial intelligence (AI), however, are challenging this paradigm. Synthesizing insights from a Cancer Moonshot workshop, we argue that systemically addressing the undruggable target space with AI requires a new conceptual framework. We highlight the failure of current target taxonomies and the need for benchmarking datasets, and re-evaluate clinical validation for novel AI-driven modalities.

    • Karen Akinsanya
    • Mohammed AlQuraishi
    • Olivier Elemento
    Comments & Opinion
    Nature Biotechnology
    Volume: 43, P: 1416-1418

  • Condensates have been proposed to create a distinct chemical solvating environment. In vitro condensate screens suggest that condensate chemical environments influence the intracellular distribution of small molecules.

    • Henry R. Kilgore
    • Peter G. Mikhael
    • Richard A. Young
    Research
    Nature Chemical Biology
    Volume: 20, P: 291-301

  • The systematic categorization of human enhancers by their cofactor dependencies provides a conceptual framework to understand the sequence and chromatin diversity of enhancers and their roles in different gene-regulatory programmes.

    • Christoph Neumayr
    • Vanja Haberle
    • Alexander Stark
    Research
    Nature
    Volume: 606, P: 406-413

  • RNA polymerase II with a hypophosphorylated C-terminal domain preferentially incorporates into mediator condensates, and with a hyperphosphorylated C-terminal domain into splicing-factor condensates, revealing phosphorylation as a regulatory mechanism in condensate preference.

    • Yang Eric Guo
    • John C. Manteiga
    • Richard A. Young
    Research
    Nature
    Volume: 572, P: 543-548