Early initiation of dialysis has been recommended by guidelines over the past two decades, but recent studies and a randomized, controlled trial indicate that patients who start dialysis early might in fact have worse outcomes. The authors of this Review discuss studies of early and late dialysis initiation and highlight factors that influence the association between dialysis initiation and outcomes in transplant-naive patients with chronic kidney disease and in patients with a failed allograft.
- Miklos Z. Molnar
- Akinlolu O. Ojo
- Kamyar Kalantar-Zadeh
