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Showing 1–3 of 3 results

Advanced filters: Author: Ann M. Wehman Clear advanced filters

Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures

Visualising certain organelles and their dynamics is challenging in living cells. Here the authors co-opt selective degradation to label membrane-bound compartments in worm embryos and mammalian cells, revealing membrane topology during cell division.

Katharina B. Beer
Gholamreza Fazeli
Ann M. Wehman
ResearchOpen Access02 Aug 2019
Nature Communications

Volume: 10, P: 1-16
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

Florencio Porto Freitas
Hamed Alborzinia
José Pedro Friedmann Angeli
Research31 Jan 2024
Nature

Volume: 626, P: 401-410
The power of imaging to understand extracellular vesicle biology in vivo

This Review describes the state of the art in imaging extracellular vesicles in animals to study their release, biodistribution and uptake, and covers labeling strategies, microscopy methods and discoveries made in model organisms.

Frederik J. Verweij
Leonora Balaj
Guillaume van Niel
Reviews26 Aug 2021
Nature Methods

Volume: 18, P: 1013-1026