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Showing 1–6 of 6 results
Advanced filters: Author: Ann V. Hertzel Clear advanced filters

  • A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

    • Ken Suzuki
    • Konstantinos Hatzikotoulas
    • Eleftheria Zeggini
    ResearchOpen Access
    Nature
    Volume: 627, P: 347-357

  • This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

    • Sheng Li
    • Paula A. Agudelo Garcia
    • Rong Fan
    Reviews
    Nature Genetics
    Volume: 57, P: 2381-2394

  • In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

    • Anne Loft
    • Margo P. Emont
    • Evan D. Rosen
    Reviews
    Nature Metabolism
    Volume: 7, P: 875-894

  • Senescent cells have complex and important roles in cancer and ageing, but they are quite rare and difficult to characterize in tissues in vivo. In this Expert Recommendation, the SenNet Biomarkers Working Group discusses recent advances in detecting and characterizing cellular senescence and provides recommendations for senescence markers in 14 human and mouse tissues.

    • Vidyani Suryadevara
    • Adam D. Hudgins
    • Nicola Neretti
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 1001-1023

  • Marie Loh, Weihua Zhang et al. use a genome-wide association study meta-analysis to examine variants associated with Type 2 diabetes (T2D) in South Asian and European ancestry cohorts. Their results provide further insights into the genetic mechanisms underlying T2D across ancestral populations.

    • Marie Loh
    • Weihua Zhang
    • John C. Chambers
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-10