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Showing 1–3 of 3 results
Advanced filters: Author: Anna Chrostek-Grashoff Clear advanced filters

  • Talin is a well-known regulator of cell adhesion and intracellular force transmission in animals. Here, the authors demonstrate that talin’s mechanical function is evolutionarily conserved and already established in unicellular eukaryotes.

    • Srishti Rangarajan
    • Lena Espeter
    • Carsten Grashoff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop a mouse model to demonstrate that the presence of metavinculin is not as critical for heart muscle function as previously thought.

    • Verena Kanoldt
    • Carleen Kluger
    • Carsten Grashoff
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Austen et al. generated talin biosensors to study integrin-based force transduction. They report that extracellular rigidity sensing requires talin’s mechanical engagement and find talin isoform-dependent effects in integrin-mediated mechanosensing.

    • Katharina Austen
    • Pia Ringer
    • Carsten Grashoff
    Research
    Nature Cell Biology
    Volume: 17, P: 1597-1606