Pinho et al. show that VCAM1 and MHC-I cooperate to provide a ‘don’t-eat-me’ signal that prevents haematopoietic stem cells clearance by mononuclear phagocytes, and also that VCAM1 can be hijacked by cancer cells to escape innate immune surveillance.
- Sandra Pinho
- Qiaozhi Wei
- Paul S. Frenette