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Showing 1–10 of 10 results
Advanced filters: Author: Anna H. Bizard Clear advanced filters

  • A method that uses a combination of optical trapping, fluorescence microscopy and microfluidics to analyse the internal structure of chromosomes shows that there is a distinct nonlinear stiffening of the chromosome in response to tension.

    • Anna E. C. Meijering
    • Kata Sarlós
    • Gijs J. L. Wuite
    ResearchOpen Access
    Nature
    Volume: 605, P: 545-550

  • Hertz et al. use CRISPR screening to identify genetic vulnerabilities to inhibition of SUMOylation in human cells. They show that SUMO exerts its essential role in cell proliferation via NIP45- and BTRR-PICH-mediated DNA catenane resolution pathways.

    • Emil P. T. Hertz
    • Ignacio Alonso-de Vega
    • Niels Mailand
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1303-1313

  • Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA.

    • Kata Sarlós
    • Andreas S. Biebricher
    • Ian D. Hickson
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 868-876

  • During mitosis the translocase PICH binds to ultrafine bridges formed from DNA catenanes that are unresolved by topoisomerase II. In this study, the authors show that PICH stimulates toposiomerase II activity and that they cooperate to resolve these structures.

    • Christian F. Nielsen
    • Diana Huttner
    • Ian D. Hickson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork remodelling as maintaining genome stability in embryos.

    • Akshay K. Ahuja
    • Karolina Jodkowska
    • Massimo Lopes
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Here the authors probe the cleavage and gate opening of single-stranded DNA by the human topoisomerase TRR using a unique single-molecule strategy to reveal structural plasticity in response to both double-stranded DNA and the helicase BLM.

    • Julia A. M. Bakx
    • Andreas S. Biebricher
    • Erwin J. G. Peterman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • PICH and Topoisomerase 3a together introduce positive supercoiling into DNA, which could aid efficient sister-chromatid disjunction during mitosis.

    • Anna H. Bizard
    • Jean-Francois Allemand
    • Ian D. Hickson
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 267-274

  • The 'dissolvasome', composed of TopIIIα, BLM and RMI proteins, coordinates DNA-helicase and DNA-topoisomerase activities to resolve double Holliday junctions (dHJs) generated during DNA recombination and repair. The first crystal structure of a human TopIIIα–Rmi1 subcomplex provides insights into how topoisomerase is stimulated to promote dHJ decatenation.

    • Nicolas Bocquet
    • Anna H Bizard
    • Nicolas H Thomä
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 261-268