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Showing 1–5 of 5 results
Advanced filters: Author: Anna Hadjihambi Clear advanced filters

  • The liver is a key metabolic organ that influences metabolic homeostasis by communicating with the central nervous system. This Review discusses the role of gut–liver–brain communication in chronic liver disease, highlighting underlying mechanisms and signalling pathways.

    • Matthew Siddle
    • Rocío Gallego Durán
    • Anna Hadjihambi
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 23, P: 166-188

  • This study explores how adenosine A2B receptors can act as astrocytic sensors of brain metabolic activity and how cAMP signalling in astrocytes may support core brain functions such as sleep and memory.

    • Shefeeq M. Theparambil
    • Olga Kopach
    • Alexander V. Gourine
    ResearchOpen Access
    Nature
    Volume: 632, P: 139-146

  • The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.

    • Patrick S. Hosford
    • Jack A. Wells
    • Alexander V. Gourine
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • This Review describes inter-organ ammonia metabolism in liver disease and mechanisms underlying the pathogenic effect of hyperammonaemia in hepatic encephalopathy, liver disease progression in metabolic dysfunction-associated steatotic liver disease, immune dysfunction and hepatocellular carcinoma. It also addresses the principles of treating hyperammonaemia.

    • Rocío Gallego-Durán
    • Anna Hadjihambi
    • Manuel Romero-Gómez
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 21, P: 774-791