Nature Search

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors

Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neutrophil differentiation.

David B. Chou
Brooke A. Furlong
Donald E. Ingber
ResearchOpen Access12 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Surveillance of multiple congenital anomalies; searching for new associations

Joan K. Morris
Jorieke E. H. Bergman
Ester Garne
ResearchOpen Access05 Dec 2023
European Journal of Human Genetics

Volume: 32, P: 407-412
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

Combining analysis of host proteome and transcriptome perturbations induced by tumour virus proteins with ongoing genome-wide studies of cancer facilitates the prioritization of cancer genes.

Orit Rozenblatt-Rosen
Rahul C. Deo
Marc Vidal
Research18 Jul 2012
Nature

Volume: 487, P: 491-495
Intracytoplasmic membranes develop in Geobacter sulfurreducens under thermodynamically limiting conditions

Ethan Howley
Anna Mangus
César I. Torres
ResearchOpen Access07 Apr 2023
npj Biofilms and Microbiomes

Volume: 9, P: 1-8
BET domain co-regulators in obesity, inflammation and cancer

The bromodomain is a highly conserved motif found in proteins that interact with chromatin. Small molecules that inhibit bromodomain and extraterminal (BET) proteins have been described, and this Review examines these developments and discusses the implications for small molecule epigenetic targeting of chromatin networks in cancer.

Anna C. Belkina
Gerald V. Denis
Reviews22 Jun 2012
Nature Reviews Cancer

Volume: 12, P: 465-477

Quick links

Search

Filter By:

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors

Surveillance of multiple congenital anomalies; searching for new associations

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

Intracytoplasmic membranes develop in Geobacter sulfurreducens under thermodynamically limiting conditions

BET domain co-regulators in obesity, inflammation and cancer

Search

Quick links