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Showing 1–3 of 3 results
Advanced filters: Author: Anna M. Kietrys Clear advanced filters

  • The presence of an N1 methyl group on adenine bases in DNA and RNA was thought to be a form of damage. Results now show that it also occurs at specific sites in messenger RNAs, where it affects protein expression. See Article p.441

    • Anna M. Kietrys
    • Eric T. Kool
    News & Views
    Nature
    Volume: 530, P: 423-424

  • Now a reactivity-based RNA profiling strategy can measure the global off-target transcriptome interactions of small-molecule drugs at single-nucleotide resolution. Using this approach, three FDA-approved drugs were evaluated, uncovering pervasive drug–RNA interactions and interactions that perturb RNA functions in cells.

    • Linglan Fang
    • Willem A. Velema
    • Eric T. Kool
    Research
    Nature Chemistry
    Volume: 15, P: 1374-1383