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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection

Glutaminase is a mitochondrial complex that deaminates glutamine to form glutamate. Here the authors investigate inorganic-phosphate-induced enzyme filamentation, revealing an allosteric mechanism and roles of filamentous glutaminase in mitochondrial morphology and recycling.

Douglas Adamoski
Marilia Meira Dias
Sandra Martha Gomes Dias
Research19 Oct 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1902-1912
White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a functional axon-myelin unit.

Martin Meschkat
Anna M. Steyer
Wiebke Möbius
ResearchOpen Access04 Mar 2022
Nature Communications

Volume: 13, P: 1-18
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

The inner hair cells (IHCs) within the cochlea convey sound information and have been thought to be electrically and metabolically independent from each other. Here authors report that a subset of IHCs are electrochemically coupled in ‘mini-syncytia’.

Philippe Jean
Tommi Anttonen
Tobias Moser
ResearchOpen Access25 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings

Ultrastructural analysis of nuclear membrane topology and assembling NPCs reveals how mitotic cells can rapidly establish a closed nuclear compartment while at the same time making it transport competent.

Shotaro Otsuka
Anna M. Steyer
Jan Ellenberg
Research27 Nov 2017
Nature Structural & Molecular Biology

Volume: 25, P: 21-28
Photonic-chip assisted correlative light and electron microscopy

Tinguely et al. develop a photonic chip-based correlative light-electron microscopy system to generate co-registered multi-modal total internal reflection fluorescence microscopy (TIRF) and electron microscopy (EM) images of biological samples at nanometer scale.

Jean-Claude Tinguely
Anna Maria Steyer
Balpreet Singh Ahluwalia
ResearchOpen Access07 Dec 2020
Communications Biology

Volume: 3, P: 1-7
A mind-brain-body dataset of MRI, EEG, cognition, emotion, and peripheral physiology in young and old adults

Anahit Babayan
Miray Erbey
Arno Villringer
ResearchOpen Access12 Feb 2019
Scientific Data

Volume: 6, P: 1-21
AMST: Alignment to Median Smoothed Template for Focused Ion Beam Scanning Electron Microscopy Image Stacks

Julian Hennies
José Miguel Serra Lleti
Yannick Schwab
ResearchOpen Access06 Feb 2020
Scientific Reports

Volume: 10, P: 1-10

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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings

Photonic-chip assisted correlative light and electron microscopy

A mind-brain-body dataset of MRI, EEG, cognition, emotion, and peripheral physiology in young and old adults

AMST: Alignment to Median Smoothed Template for Focused Ion Beam Scanning Electron Microscopy Image Stacks

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