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Cell Death & Disease (2)
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Advanced filters: Author: Anna Pellattiero Clear advanced filters

The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

Mitochondrial cristae shape influences apoptosis and respiration. Here the authors show that the mitochondrial fusion protein OPA1 protects mitochondria from dysfunction by promoting ATP synthase oligomerization and reversal activity.

Rubén Quintana-Cabrera
Charlotte Quirin
Luca Scorrano
ResearchOpen Access24 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Metastatic breast cancer cells are selectively dependent on the mitochondrial cristae-shaping protein OPA1

Antigoni Diokmetzidou
Aurora Maracani
Luca Scorrano
ResearchOpen Access21 Jul 2025
Cell Death & Disease

Volume: 16, P: 1-10
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line

Masafumi Noguchi
Susumu Kohno
Atsuko Kasahara
ResearchOpen Access05 Apr 2023
Cell Death & Disease

Volume: 14, P: 1-10