Nature Search

Investigating the analytical robustness of the social and behavioural sciences

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Balazs Aczel
Barnabas Szaszi
Brian A. Nosek
Research01 Apr 2026
Nature

Volume: 652, P: 135-142
Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB

CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca²⁺ handling and fusion dynamics are impaired, revealing their dependence on CLPB.

Donato D’Angelo
Víctor H. Sánchez-Vázquez
György Hajnóczky
ResearchOpen Access21 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Direct evidence for phosphorus limitation on Amazon forest productivity

Nutrient manipulation of low-phosphorus soil in an old growth Amazon rainforest shows that phosphorus availability drives forest productivity and is likely to limit the response to increasing atmospheric CO₂ concentrations.

Hellen Fernanda Viana Cunha
Kelly M. Andersen
Carlos Alberto Quesada
Research10 Aug 2022
Nature

Volume: 608, P: 558-562
Metal-free photochemical silylations and transfer hydrogenations of benzenoid hydrocarbons and graphene

Baird’s rules say that the first triplet state of benzene displays antiaromatic character. Here, the authors exploit this to show that aromatic molecules can undergo rapid transfer hydrogenation or silylations without the need for metal catalysts when photochemcially excited into this state.

Raffaello Papadakis
Hu Li
Henrik Ottosson
ResearchOpen Access06 Oct 2016
Nature Communications

Volume: 7, P: 1-10
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca²⁺ accumulation in spinobulbar muscular atrophy skeletal muscle

Marchioretti and colleagues show that in the skeletal muscle of SBMA mice and patients there is an early, but reversible alteration of expression of genes involved in muscle contraction and of mitochondrial respiration, followed by accumulation of calcium inside the mitochondria, which is concomitant with the onset of motor dysfunction, and late alteration of muscle structure.

Caterina Marchioretti
Giulia Zanetti
Maria Pennuto
ResearchOpen Access06 Feb 2023
Nature Communications

Volume: 14, P: 1-19
Mitochondria as sensors and regulators of calcium signalling

Ca²⁺ uptake through specialized transporters allows mitochondria to act as buffers of intracellular Ca²⁺ levels. Moreover, mitochondrial Ca²⁺ signalling regulates vital processes, including metabolism and cell death. Therefore, mitochondrial Ca²⁺signalling remains at the epicentre of cell biological research.

Rosario Rizzuto
Diego De Stefani
Cristina Mammucari
Reviews01 Aug 2012
Nature Reviews Molecular Cell Biology

Volume: 13, P: 566-578
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Diego De Stefani
Anna Raffaello
Rosario Rizzuto
Research19 Jun 2011
Nature

Volume: 476, P: 336-340
Creatine transporter (SLC6A8) knockout mice exhibit reduced muscle performance, disrupted mitochondrial Ca²⁺ homeostasis, and severe muscle atrophy

Irene Pertici
Donato D’Angelo
Anna Raffaello
ResearchOpen Access14 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-13
Publisher Correction: Parkin-dependent regulation of the MCU complex component MICU1

Alessandra Matteucci
Maria Patron
Tito Calì
Amendments and CorrectionsOpen Access12 Mar 2019
Scientific Reports

Volume: 9, P: 1
Parkin-dependent regulation of the MCU complex component MICU1

Alessandra Matteucci
Maria Patron
Tito Calì
ResearchOpen Access21 Sept 2018
Scientific Reports

Volume: 8, P: 1-13
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

Michael Duchen, Francesco Muntoni, Eamonn Sheridan and colleagues show that loss-of-function mutations in MICU1 cause a recessive disorder characterized by proximal myopathy, learning difficulties and progressive extrapyramidal motor deficits. The mutations alter mitochondrial calcium homeostasis, leading to mitochondrial damage and dysfunction.

Clare V Logan
György Szabadkai
Eamonn Sheridan
Research15 Dec 2013
Nature Genetics

Volume: 46, P: 188-193
Gait training using a robotic hip exoskeleton improves metabolic gait efficiency in the elderly

Elena Martini
Simona Crea
Nicola Vitiello
ResearchOpen Access09 May 2019
Scientific Reports

Volume: 9, P: 1-12

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Investigating the analytical robustness of the social and behavioural sciences

Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB

Direct evidence for phosphorus limitation on Amazon forest productivity

Metal-free photochemical silylations and transfer hydrogenations of benzenoid hydrocarbons and graphene

Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca²⁺ accumulation in spinobulbar muscular atrophy skeletal muscle

Mitochondria as sensors and regulators of calcium signalling

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Creatine transporter (SLC6A8) knockout mice exhibit reduced muscle performance, disrupted mitochondrial Ca²⁺ homeostasis, and severe muscle atrophy

Publisher Correction: Parkin-dependent regulation of the MCU complex component MICU1

Parkin-dependent regulation of the MCU complex component MICU1

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

Gait training using a robotic hip exoskeleton improves metabolic gait efficiency in the elderly

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