Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immunogenicity in a small animal model.
- Philip J. M. Brouwer
- Aleksandar Antanasijevic
- Rogier W. Sanders
