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How can resistant hypertension be identified and prevented?

Resistant hypertension is difficult to treat. In a Perspectives, Solini and Ruilope argue that many patients with resistant hypertension actually have mismanaged primary hypertension. They discuss how to identify misclassified patients and how to correctly manage hypertension.

Anna Solini
Luis M. Ruilope
Reviews05 Mar 2013
Nature Reviews Cardiology

Volume: 10, P: 293-296
SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

In patients with type 2 diabetes mellitus, sodium-glucose cotransporter 2 (SGLT2) inhibition improves glycaemic control to a therapeutically useful extent by reducing glucose reabsorption in the kidneys. This Review covers the rationale, physiological consequences and clinical application of pharmacological SGLT2 inhibition and also discusses the potential clinical merits and disadvantages of these agents.

Ele Ferrannini
Anna Solini
Reviews07 Feb 2012
Nature Reviews Endocrinology

Volume: 8, P: 495-502
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.

Francesca D’Addio
Anna Maestroni
Paolo Fiorina
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-14
SGLT inhibition in T1DM — definite benefit with manageable risk

Two phase III trials using the selective SGLT2 inhibitor dapagliflozin or the dual SGLT2/SGLT1 inhibitor sotagliflozin in patients with type 1 diabetes mellitus show similar clinical benefit (reduction of HbA_1c, body weight, blood pressure and insulin dose). The risk of hypoglycaemia and diabetic ketoacidosis with these inhibitors can be managed by careful adjustment of insulin therapy.

Ele Ferrannini
Anna Solini
News & Views27 Oct 2017
Nature Reviews Endocrinology

Volume: 13, P: 698-699
From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function

Peggy Sekula
Katja Dettmer
Anna Köttgen
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-9
Periodontitis affects glucoregulatory hormones in severely obese individuals

Anna Solini
Jean Suvan
Filippo Graziani
ResearchOpen Access19 Nov 2018
International Journal of Obesity

Volume: 43, P: 1125-1129
miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts their In-Vivo Angiogenic Potential

Claudia Cavallari
Federico Figliolini
Maria Felice Brizzi
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-13

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How can resistant hypertension be identified and prevented?

SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

SGLT inhibition in T1DM — definite benefit with manageable risk

From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function

Periodontitis affects glucoregulatory hormones in severely obese individuals

miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts their In-Vivo Angiogenic Potential

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How can resistant hypertension be identified and prevented?

SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

SGLT inhibition in T1DM — definite benefit with manageable risk

From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function

Periodontitis affects glucoregulatory hormones in severely obese individuals

miR-130a and Tgfβ Content in Extracellular Vesicles Derived from the Serum of Subjects at High Cardiovascular Risk Predicts their In-Vivo Angiogenic Potential

Search

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