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Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Onyeogaziri et al. show that the formation of neutrophil extracellular traps contributes to a chronic wound state in cerebral cavernous malformation, while inhibition of these traps with CI-amidine establishes a healthier microenvironment and promotes endothelial cell quiescence, suggesting use of CI-amidine as a potential therapeutic strategy.

Favour C. Onyeogaziri
Ross Smith
Peetra U. Magnusson
ResearchOpen Access04 Dec 2024
Nature Cardiovascular Research

Volume: 3, P: 1549-1567
Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

Filip Pano
Laura Bub
Fabio Rabelo Melo
ResearchOpen Access27 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-17
GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).

Daniel Eriksson
Ellen Christine Røyrvik
Eystein Sverre Husebye
ResearchOpen Access11 Feb 2021
Nature Communications

Volume: 12, P: 1-14
VEGF receptor signalling ? in control of vascular function

Vascular endothelial growth factors (VEGFs) regulate vascular development during embryogenesis and angiogenesis in the adult. The recently developed cancer treatments that target VEGF receptor activation highlight the clinical relevance of inhibiting VEGF pathways that are exaggerated in pathological angiogenesis.

Anna-Karin Olsson
Anna Dimberg
Lena Claesson-Welsh
Reviews01 May 2006
Nature Reviews Molecular Cell Biology

Volume: 7, P: 359-371
No common founder for C9orf72 expansion mutation in Sweden

Huei-Hsin Chiang
Charlotte Forsell
Caroline Graff
Research25 Aug 2016
Journal of Human Genetics

Volume: 62, P: 321-324
Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm

Itay Zamir
Elisabeth Stoltz Sjöström
Magnus Domellöf
ResearchOpen Access18 Feb 2019
Pediatric Research

Volume: 86, P: 115-121

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Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

VEGF receptor signalling ? in control of vascular function

No common founder for C9orf72 expansion mutation in Sweden

Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm

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Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

VEGF receptor signalling ? in control of vascular function

No common founder for C9orf72 expansion mutation in Sweden

Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm

Search

Quick links