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Advanced filters: Author: Anna-Lisa Fuchs Clear advanced filters

  • Using methyl group and fluorine NMR spectroscopic methods, Overbeck et al revealed that the dynamics of the eukaryotic 5′→3′ exoribonuclease Xrn2 in the region around the active site are correlated with its catalytic activity.

    • Jan H. Overbeck
    • David Stelzig
    • Remco Sprangers
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 1152-1160

  • Structural and biochemical studies of scavenger decapping enzyme identify conformational changes induced by substrate binding to a second binding site that occur faster than catalytic turnover, such that high substrate concentrations inhibit enzyme activity.

    • Ancilla Neu
    • Ursula Neu
    • Remco Sprangers
    Research
    Nature Chemical Biology
    Volume: 11, P: 697-704