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Signal Transduction and Targeted Therapy (1)
Nature Immunology (1)
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Showing 1–3 of 3 results

Advanced filters: Author: Anna-Maria Herzner Clear advanced filters

G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes

Anna-Maria Herzner
Steven Wolter
Martin Schlee
ResearchOpen Access12 Dec 2016
Scientific Reports

Volume: 6, P: 1-16
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Truncated reverse transcription of HIV RNA produces a single-stranded DNA intermediate with a unique Y-DNA stem-loop structure flanked by unpaired guanines. Schlee and colleagues show this Y-DNA activates cGAS to elicit the production of type I interferon.

Anna-Maria Herzner
Cristina Amparo Hagmann
Martin Schlee
Research07 Sept 2015
Nature Immunology

Volume: 16, P: 1025-1033
The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis

Anna-Maria Herzner
Martin Schlee
Eva Bartok
Research HighlightsOpen Access09 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3