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Showing 1–3 of 3 results
Advanced filters: Author: Annabel Borg Clear advanced filters

  • The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.

    • Antoni G. Wrobel
    • Donald J. Benton
    • Steven J. Gamblin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.

    • Antoni G. Wrobel
    • Donald J. Benton
    • Steven J. Gamblin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-6

  • Older people have suboptimal responses to primary series vaccines, which can place them at risk for adverse coronavirus disease 2019 outcomes. Here the authors show that booster vaccines provide a substantial increase in antibody levels in the short term but that there is significant waning 100 d after booster shots.

    • Gokhan Tut
    • Tara Lancaster
    • Paul Moss
    ResearchOpen Access
    Nature Aging
    Volume: 3, P: 93-104