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Showing 1–4 of 4 results
Advanced filters: Author: Annabel Sorby-Adams Clear advanced filters

  • Portable, low-field MRI of the brain may facilitate assessment of patients with Alzheimer’s disease. Here, the authors present and validate an end-to-end pipeline to quantify brain morphometry using LF-MRI in patients with dementia.

    • Annabel J. Sorby-Adams
    • Jennifer Guo
    • W. Taylor Kimberly
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Targeting oncogenic ALK activity in neuroblastoma is an attractive therapeutic strategy but success has been limited by resistance to ALK inhibitors. Here, the authors identify loss of miR-1304-5p as a driver of ALK inhibitor resistance via regulation of NRAS, and therapeutically target this axis with the addition of a farnesyltransferase inhibitor in preclinical models of neuroblastoma.

    • Perla Pucci
    • Liam C. Lee
    • Suzanne D. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • The advent of portable, low-field MRI is transforming clinical brain imaging. This Review discusses the bioengineering advances that have enabled scanning outside the controlled environment of conventional MRI suites, enhancing access to neuroimaging. Ongoing development and innovation will increase the real-world application of MRI.

    • W. Taylor Kimberly
    • Annabel J. Sorby-Adams
    • Kevin N. Sheth
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 617-630