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Showing 1–3 of 3 results
Advanced filters: Author: Annabelle Batten Clear advanced filters

  • Progress in the development of RNA-based therapeutics has been accelerated by the identification of organ-enriching carriers and cell-specific targeting conjugates, leading to their approval for a range of indications. However, attempts to develop RNA-based therapeutics for kidney diseases have proved challenging. This Review describes the physiological, technological and pharmacological hurdles that need to be overcome to realize the potential of RNA therapeutic approaches to kidney diseases.

    • Jurriën Prins
    • Annabelle Biscans
    • Eric P. van der Veer
    Reviews
    Nature Reviews Nephrology
    Volume: 22, P: 12-29

  • The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.

    • Eizo Marutani
    • Masanobu Morita
    • Fumito Ichinose
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19