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Showing 1–5 of 5 results
Advanced filters: Author: Anne Dueck Clear advanced filters

  • Argonaute (Ago) proteins that cleave target RNAs are known as slicer enzymes. Extensive mutagenesis studies combined with in vitro cleavage assays and structural modeling have now enabled catalytically inactive human Ago1 and Ago3 to be turned into slicer enzymes, providing insight into the molecular basis of human Ago1 and Ago3 inactivity.

    • Judith Hauptmann
    • Anne Dueck
    • Gunter Meister
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 814-817

  • Plasmacytoid dendritic cells monitor the bone marrow for apoptotic megakaryocytes (MKs) and deliver IFNα to the MK niche, triggering local on-demand proliferation and maturation of MK progenitors.

    • Florian Gaertner
    • Hellen Ishikawa-Ankerhold
    • Steffen Massberg
    ResearchOpen Access
    Nature
    Volume: 631, P: 645-653

  • MicroRNAs (miRNAs) regulate gene expression in many different organisms and cell types. In mouse embryonic stem cells, a regulatory circuit that involves let-7 and its target mLin41, which encodes an E3 ubiquitin ligase, facilitates polyubiquitylation of the miRNA effector Argonaute 2 (Ago2) and targets it for degradation.

    • Anne Dueck
    • Gunter Meister
    News & Views
    Nature Cell Biology
    Volume: 11, P: 1392-1393

  • An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.

    • Dena Esfandyari
    • Bio Maria Ghéo Idrissou
    • Stefan Engelhardt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The nature of small RNA species derived from gene termini and intron-exon junctions is now further examined. By sequencing transcripts between 12 and 100 nucleotides derived from cells depleted for RNA decay factors as well as those associated with Argonaute proteins, insights into how these RNAs are produced is provided. Moreover, new small RNAs are identified.

    • Eivind Valen
    • Pascal Preker
    • Torben Heick Jensen
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1075-1082