oskar mRNA localization to the posterior pole of the Drosophila melanogaster oocyte requires splicing of the first intron and the exon junction complex (EJC). In vitro and in vivo analyses demonstrate that splicing has a dual role in oskar mRNA localization by generating a secondary structural element required for RNP motility and depositing the EJC required for mRNA transport.
- Sanjay Ghosh
- Virginie Marchand
- Anne Ephrussi
