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Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems

A study by Leprince et al. shows the effectiveness of Streptococcus thermophilus defense systems against dairy phages, their synergy with CRISPR-Cas, and the absence of fitness cost under lab or industrial conditions when they are chromosomally integrated.

Audrey Leprince
Justine Lefrançois
Sylvain Moineau
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Failure of human rhombic lip differentiation underlies medulloblastoma formation

Derailed differentiation of human-specific progenitors of the developing cerebellar rhombic lip is the cause of group 4 medulloblastoma, the most common childhood brain tumour.

Liam D. Hendrikse
Parthiv Haldipur
Michael D. Taylor
Research21 Sept 2022
Nature

Volume: 609, P: 1021-1028
ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip

Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medulloblastoma.

John J. Y. Lee
Ran Tao
Michael D. Taylor
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 88-102
Early dorsomedial tissue interactions regulate gyrification of distal neocortex

The contribution of long-range signaling to cortical gyrification remains poorly understood. In this study, authors demonstrate that the combined genetic loss of transcription factors Lmx1a and Lmx1b, expressed in the telencephalic dorsal midline neuroepithelium and head mesenchyme, respectively, induces gyrification in the mouse neocortex

Victor V. Chizhikov
Igor Y. Iskusnykh
Kathleen J. Millen
ResearchOpen Access15 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Uncovering the mode of action of engineered T cells in patient cancer organoids

The dynamics and molecular mechanisms of T cell therapies are probed in cancer organoids.

Johanna F. Dekkers
Maria Alieva
Anne C. Rios
ResearchOpen Access25 Jul 2022
Nature Biotechnology

Volume: 41, P: 60-69
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation

Liam D. Hendrikse
Parthiv Haldipur
Michael D. Taylor
Amendments and Corrections29 Nov 2022
Nature

Volume: 612, P: E12
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98

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Mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems

Failure of human rhombic lip differentiation underlies medulloblastoma formation

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip

Early dorsomedial tissue interactions regulate gyrification of distal neocortex

Uncovering the mode of action of engineered T cells in patient cancer organoids

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation

Genetic mechanisms of critical illness in COVID-19

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