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Showing 1–3 of 3 results
Advanced filters: Author: Anne M. van der Leun Clear advanced filters

  • Immune checkpoint blockade has become standard care for patients with recurrent metastatic head and neck squamous cell carcinoma (HNSCC). Here the authors present the results of a non-randomized phase Ib/IIa trial, reporting safety and efficacy of neoadjuvant nivolumab monotherapy and nivolumab plus ipilimumab prior to standard-of-care surgery in patients with HNSCC. .

    • Joris L. Vos
    • Joris B. W. Elbers
    • Charlotte L. Zuur
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Recent single-cell RNA-sequencing studies have revealed a range of intratumoural T cell states, both within and between patients. This Review outlines the CD8+ T cell states that have been identified in human tumours and the potential roles they play in tumour control as well as how they are influenced by immune checkpoint blockade.

    • Anne M. van der Leun
    • Daniela S. Thommen
    • Ton N. Schumacher
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 218-232