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Showing 1–8 of 8 results
Advanced filters: Author: Anne de Dreu Clear advanced filters

  • The rational design and implementation of synthetic mammalian communication systems can unravel fundamental design principles of cell communication circuits and offer a framework for engineering of designer cell consortia with potential applications in cell therapeutics. Here the authors present a synthetic communication platform in mammalian cells based on diffusible dipeptide ligands and synthetic receptors, that is by design highly orthogonal, scalable, and programmable.

    • Anna-Maria Makri Pistikou
    • Glenn A. O. Cremers
    • Tom F. A. de Greef
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Cytokines are key regulators of the immune system and can be recombinantly designed as therapeutics for immune-related disorders. However, the severe toxicity of recombinant cytokines limits their clinical translation. In this Review, the authors highlight bioengineering approaches for the design of clinically applicable and safe cytokine-based therapeutics.

    • Jeroen Deckers
    • Tom Anbergen
    • Willem J. M. Mulder
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 286-303

  • Trained immunity is a form of nonspecific immune memory, harboured within the innate immune system. This Review discusses nanomedicine platforms to therapeutically regulate trained immunity for the treatment of various conditions, including cancer, inflammation and infection.

    • Mandy M. T. van Leent
    • Bram Priem
    • Willem J. M. Mulder
    Reviews
    Nature Reviews Materials
    Volume: 7, P: 465-481