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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic targeting in vivo.

Anne-Katrien Stark
Anita Chandra
Klaus Okkenhaug

ResearchOpen Access09 Aug 2018

Nature Communications

Volume: 9, P: 1-16

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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood

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