Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Annick Dejaegere Clear advanced filters

  • Activation of the PPARγ/RXRα pathway in luminal bladder cancers has mainly been linked to PPARG gene amplifications and activating point mutations in RXRα. Here, the authors identify recurrent PPARγ mutations with similar effects and elucidate the structural basis for this mutational PPARγ activation.

    • Natacha Rochel
    • Clémentine Krucker
    • Isabelle Bernard-Pierrot
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.

    • Marjorie Fournier
    • Meritxell Orpinell
    • László Tora
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • The transcription co-activator complex SAGA is recruited to promoters by transcriptional activators and promotes the formation of the pre-initiation complex. Here, the authors present the cryo-EM structure of the SAGA complex and resolve the major target of activator binding, the 430 kDa Tra1 protein.

    • Grigory Sharov
    • Karine Voltz
    • Patrick Schultz
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7