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Showing 1–2 of 2 results
Advanced filters: Author: Annie Hackland Clear advanced filters

  • Advances in cellular and spatial profiling technologies have rapidly expanded the understanding of fibroblast heterogeneity within the target tissues of disease. In 2025, there has been a shift towards a consensus definition of shared cross-tissue fibroblast states and a greater understanding of their molecular drivers and disease-relevant effector functions.

    • Adam P. Croft
    • Annie Hackland
    News & Views
    Nature Reviews Rheumatology
    Volume: 22, P: 86-88

  • The phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults?

    • Annie Hackland
    • Adam P. Croft
    News & Views
    Nature Reviews Rheumatology
    Volume: 19, P: 132-133