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Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice

This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potential approach to treat age- and obesity-related metabolic disease.

Eok-Cheon Kim
Han-Byul Jung
So-Young Park
ResearchOpen Access31 Mar 2026
Nature Communications

Volume: 17, P: 1-26
The Habits of the Cuckoo

ANNIE LEY
Research09 Jan 1896
Nature

Volume: 53, P: 223
The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

The Contaminant Repository for Affinity Purification (CRAPome) is a database of annotated negative control-data that can be used for filtering out nonspecific interactions in affinity purification-mass spectrometry experiments.

Dattatreya Mellacheruvu
Zachary Wright
Alexey I Nesvizhskii
Research07 Jul 2013
Nature Methods

Volume: 10, P: 730-736
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16

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