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Showing 1–2 of 2 results
Advanced filters: Author: Annie Zappone Clear advanced filters

  • R-loops cause genome instability by creating conflicts with transcription and replication. Here the authors show that SFPQ binds R-loops at repetitive elements, recruits DAXX and maintains H3.3 deposition. Loss of SFPQ leads to genome instability and cGAS–STING activation, correlating with improved sarcoma patient survival.

    • Alessandro Ferrando
    • Michele Giaquinto
    • Stefan Schoeftner
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-22

  • Telomerase protects chromosome ends in stem cells and cancer cells. Here the authors show that Trimethylguaonsine Synthase 1 (TGS-1) – dependent trimethylguanosine capping of the RNA component of the human telomerase complex has an important role in directing telomere dependent telomere maintenance and suppressing the ALT pathway in cancer cells.

    • Valentina Buemi
    • Odessa Schillaci
    • Stefan Schoeftner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15