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Showing 1–2 of 2 results
Advanced filters: Author: Anniesha Hack Clear advanced filters

  • Mutations in the gene that encodes the endosomal cation/proton antiporter NHE9 are implicated in neuropsychiatric disorders. In this study, the authors screen autism-associated variants in the human population and identify specific variants of NHE9 that are characterized by a loss of function in astrocytes.

    • Kalyan C. Kondapalli
    • Anniesha Hack
    • Rajini Rao
    Research
    Nature Communications
    Volume: 4, P: 1-12

  • Glioblastoma multiforme is the most common and aggressive form of primary brain tumour, and in 50% of cases EFGR is mutated, amplified or upregulated. Here the authors show that NHE9 controls the amount of EGFR at the membrane surface of brain tumour-initiating stem cells by affecting the luminal pH of sorting endosomes.

    • Kalyan C. Kondapalli
    • Jose P. Llongueras
    • Rajini Rao
    Research
    Nature Communications
    Volume: 6, P: 1-15