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Showing 1–12 of 12 results
Advanced filters: Author: Annika Fendler Clear advanced filters

  • High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

    • Oriol Pich
    • Sophia Ward
    • Nicholas McGranahan
    ResearchOpen Access
    Nature
    P: 1-11

  • Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.

    • Annika Fendler
    • Scott T. C. Shepherd
    • Samra Turajlic
    ResearchOpen Access
    Nature Cancer
    Volume: 2, P: 1305-1320

  • Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blocked by the concomitant inhibition of the NOTCH and WNT pathways.

    • Annika Fendler
    • Daniel Bauer
    • Walter Birchmeier
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.

    • Annika Fendler
    • Lewis Au
    • Samra Turajlic
    ResearchOpen Access
    Nature Cancer
    Volume: 2, P: 1321-1337

  • The spatial and physical nature of tumour growth remains unclear. Combining whole-tumour images from clear cell renal cell carcinoma with genomic data, the authors show more aggressive subclonal growth and metastasizing subclones in the tumour centre.

    • Yue Zhao
    • Xiao Fu
    • Kevin Litchfield
    Research
    Nature Ecology & Evolution
    Volume: 5, P: 1033-1045

  • A combined modelling and tumour analysis approach is used to study the temporal and spatial patterns of subclone evolution in the TRACERx renal study. Studying the tumour shape and spatial features of clonal diversity in early-stage tumours may allow the prediction of tumour progression and patterns of subclone diversification over time.

    • Xiao Fu
    • Yue Zhao
    • Paul A. Bates
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 6, P: 88-102

  • Vaccination against COVID-19 confers robust protection from severe disease. However, the extent to which this applies to patients with cancer remains uncertain given that these patients were excluded from most of the pivotal studies. In this Review, the authors provide an overview of the efficacy and immunogenicity of COVID-19 vaccines in patients with cancer, and discuss alternatives to vaccination for those who might be unable to develop a proficient immune response following vaccination.

    • Annika Fendler
    • Elisabeth G. E. de Vries
    • Marie von Lilienfeld-Toal
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 19, P: 385-401

  • MicroRNA secretion pathways are dysregulated in cancer, making them attractive candidate molecules for liquid biopsies and studies have shown that they are noninvasive diagnostic, prognostic and surveillance markers in urological carcinomas. However, methodological and analytical pitfalls exist and require addressing to enable future translation of microRNA analysis into clinical practice.

    • Annika Fendler
    • Carsten Stephan
    • Klaus Jung
    Reviews
    Nature Reviews Urology
    Volume: 13, P: 734-752

  • The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.

    • A. M. Mahedi Hasan
    • Paolo Cremaschi
    • Gerhardt Attard
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16