A proposed regulatory model of FABP4 in Hcy-induced macrophage inflammation in atherosclerosis of ApoE−/− mice. FABP4 activates the JAK2/STAT2 pathway via Rap1a in Hcy-induced macrophage inflammatory response and atherosclerosis in ApoE−/− mice, which is attributed to Rap1a-dependent promotion of the c-Src phosphorylation at Tyr416 and membrane translocation. SOCS1 has a negative regulatory role in FABP4-dependent activation of the JAK2/STAT2 pathway and Rap1a in macrophage inflammatory response induced by Hcy.
- Lingbo Xu
- Huiping Zhang
- Yideng Jiang
