Nature Search

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

This study investigates the HCoV-HKU1 RBD-TMPRSS2 interaction, identifying two antibody types: one that blocks RBD-TMPRSS2 binding, while the other inhibits TMPRSS2, showing broad anti-coronavirus potential.

Zhuoqian Zhao
Qi Yang
Haitao Yang
ResearchOpen Access18 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

In this work, the authors present novel PLpro inhibitors, with lead compound GZNL-P36 showing potent activity against SARS-CoV-2 variants, improving survival and reducing lung viral loads in a mouse model, offering promise for COVID−19 therapies.

Yongzhi Lu
Qi Yang
Jinsai Shang
ResearchOpen Access23 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission

Schizophrenia is a severe psychiatric disorder and the pathogenesis remains unclear. Here, the authors show a potential role for synaptotagmin-11 in schizophrenia-related behavior through dopamine over-transmission.

Yang Chen
Yuhao Gu
Changhe Wang
ResearchOpen Access04 Dec 2024
Nature Communications

Volume: 15, P: 1-23
Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping

The invasiveness of extensive craniotomy hinders large-scale cortex mapping. Here, the authors developed a flexible, shape-changing electrode array which enables minimally invasive implantation and achieves high spatiotemporal resolution brain mapping.

Shiyuan Wei
Anqi Jiang
Xiaojie Duan
ResearchOpen Access24 Jan 2024
Nature Communications

Volume: 15, P: 1-16
An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences

This study identifies a positive-feedback loop between the ACC and the VTA that mediates the mutual exacerbation between hyperalgesia and comorbid anxiodepressive-like behaviors and, thereby, the chronicity of neuropathic pain.

Qian Song
Anqi Wei
Changhe Wang
Research03 Jan 2024
Nature Neuroscience

Volume: 27, P: 272-285
Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation

Here the authors report the cryo-EM structure of Frizzeled 4 in complex with the DEP domain of Dishevelled 2. The study unveils the key mechanism of WNT signalling activation, the recruitment of dishevelled to Frizzled receptor.

Yu Qian
Zhengxiong Ma
Yuanzheng He
ResearchOpen Access02 Sept 2024
Nature Communications

Volume: 15, P: 1-12
Structural basis of ligand recognition and design of antihistamines targeting histamine H₄ receptor

The histamine H₄ receptor (H₄R) plays key roles in immune cell function. Here, the authors report structures of H₄R-Gi complex with various ligands bound, revealing distinct ligand binding modes and a basis for rational design of novel antihistamines targeting H₄R.

Ruixue Xia
Shuang Shi
Yuanzheng He
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition

Evelyne Lima-Fernandes
Alex Murison
Catherine A. O’Brien
ResearchOpen Access29 Mar 2019
Nature Communications

Volume: 10, P: 1-14
A high-density 1,024-channel probe for brain-wide recordings in non-human primates

A probe incorporating 1,024 simultaneously recorded channels with shank length up to 90 mm exhibits high chronic recording stability and enables brain-wide large-scale neural population recordings with single-cell resolution in non-human primates.

Yang Liu
Huilin Jia
Xiaojie Duan
Research24 Jun 2024
Nature Neuroscience

Volume: 27, P: 1620-1631
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Xue-Ru Fan
Ye He
Xi-Nian Zuo
ResearchOpen Access05 Aug 2025
Communications Biology

Volume: 8, P: 1-16
Development and validation of multimodal deep learning algorithms for detecting pulmonary hypertension

Wei Zhao
Zhihua Huang
Zhihong Liu
ResearchOpen Access10 Apr 2025
npj Digital Medicine

Volume: 8, P: 1-11
Identification of oleic acid as an endogenous ligand of GPR3

Yangjie Xiong
Zhenmei Xu
Yuanzheng He
ResearchOpen Access29 Jan 2024
Cell Research

Volume: 34, P: 232-244
Loss of NDUFS1 promotes gastric cancer progression by activating the mitochondrial ROS-HIF1α-FBLN5 signaling pathway

Tao Chen
Dongbao Li
Jin Zhou
ResearchOpen Access29 Aug 2023
British Journal of Cancer

Volume: 129, P: 1261-1273
Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma

Xiang Wang
Chunliang Liu
Hongyang Wang
ResearchOpen Access05 Oct 2022
Cell Discovery

Volume: 8, P: 1-23
Structural basis of Sphingosine-1-phosphate transport via human SPNS2

Yaning Duan
Nancy C. P. Leong
Yuanzheng He
CorrespondenceOpen Access20 Dec 2023
Cell Research

Volume: 34, P: 177-180
Claudin-3 inhibits tumor-induced lymphangiogenesis via regulating the PI3K signaling pathway in lymphatic endothelial cells

Ningjing Lei
Yanru Cheng
Zhihai Qin
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-13
Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity

Han Yin
Asuka Inoue
Yuanzheng He
Correspondence07 Jun 2023
Cell Research

Volume: 33, P: 644-647
Optical breast atlas as a testbed for image reconstruction in optical mammography

Yidan Xing
Yubo Duan
Nanguang Chen
ResearchOpen Access30 Sept 2021
Scientific Data

Volume: 8, P: 1-18

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