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Showing 1–8 of 8 results
Advanced filters: Author: Anthony Arnoldo Clear advanced filters

  • In a prospective study including 2,300 pediatric and adult patients with liquid and solid tumors, RNA sequencing provided actionable molecular information in 87% of cases, with applications in diagnostics and therapy matching.

    • Robert Siddaway
    • Aida I. Glembocki
    • Cynthia Hawkins
    Research
    Nature Medicine
    Volume: 31, P: 3524-3533

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.

    • Ana S. Guerreiro Stucklin
    • Scott Ryall
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • P. falciparum and vivax are responsible for most cases of malaria but are not genetically closely related and differ in their clinical and epidemiological impacts. In this study, the authors investigate the genomic and epidemiological characteristics of the two parasites in a co-endemic setting of Guyana.

    • Philipp Schwabl
    • Flavia Camponovo
    • Daniel E. Neafsey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers able to separate specific breast cancer subtypes.

    • Thomas Fleischer
    • Xavier Tekpli
    • Vessela N. Kristensen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Pladsen et al. develop Copy Aberration Regional Mapping Analysis (CARMA), an algorithm that derives motifs for copy number profiles in breast cancers by integrating several features, to predict breast cancer prognosis and stratifications. Their algorithm can detect replication and repair defects and can be used in personalized medicine.

    • Arne V. Pladsen
    • Gro Nilsen
    • Ole Christian Lingjærde
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-9