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Showing 1–10 of 10 results
Advanced filters: Author: Anthony B. Lagnado Clear advanced filters

  • Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors show that NKG7, a lysosomal protein specifically expressed in CD8 + T cells, inhibits mTORC1 function via the lysosomal proton pump, vacuolar ATPase, promoting antitumor activity and expansion of memory T cell precursors.

    • Hyoungjun Ham
    • Jacob B. Hirdler
    • Daniel D. Billadeau
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.

    • Stella Victorelli
    • Hanna Salmonowicz
    • João F. Passos
    ResearchOpen Access
    Nature
    Volume: 622, P: 627-636

  • Senescent cells accumulate with age and contribute to the functional decline of many tissues; however, their role in skeletal muscle is not well understood. Here the authors comprehensively assess cellular senescence in skeletal muscle of young and old mice and detail senescence features in subpopulations of p16+ fibroadipogenic progenitors and p21+ myofibers.

    • Xu Zhang
    • Leena Habiballa
    • Nathan K. LeBrasseur
    Research
    Nature Aging
    Volume: 2, P: 601-615

  • Autophagy declines with age, yet it is unclear if restoration of autophagy extends lifespan. Here, the authors demonstrate in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration partially reverses these phenotypes with accelerated tumorigenesis.

    • Liam D. Cassidy
    • Andrew R. J. Young
    • Masashi Narita
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Unlike artificial sweeteners, sugar promotes ingestive behavior via both gustatory and post-ingestive pathways. Tellez et al. find that separate basal ganglia circuits mediate the hedonic and nutritional actions of sugar. They demonstrate that sugar recruits a dedicated striatofugal pathway that acts to prioritize calorie-seeking over taste quality.

    • Luis A Tellez
    • Wenfei Han
    • Ivan E de Araujo
    Research
    Nature Neuroscience
    Volume: 19, P: 465-470

  • SenNet Consortium members review current and emerging methodologies for spatially resolved mapping of senescent cells. They discuss their limitations and challenges involved in the aim of creating a comprehensive atlas of senescent cells during aging.

    • Aditi U. Gurkar
    • Akos A. Gerencser
    • João F. Passos
    Reviews
    Nature Aging
    Volume: 3, P: 776-790