Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements that occur in different populations of stem cells and progenitor cells. The authors of this Review describe the common distinguishing features of these breast cancer subtypes and explain how these relate both to prognosis and to selection of the most appropriate therapy.
- Andrew H Sims
- Anthony Howell
- Robert B Clarke
