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Showing 1–3 of 3 results
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  • This article describes a mechanism through which CD4+ T cells can eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting and thereby complement the activity of CD8+ T cells and natural killer cells to advance cancer immunotherapies.

    • Bastian Kruse
    • Anthony C. Buzzai
    • Thomas Tüting
    ResearchOpen Access
    Nature
    Volume: 618, P: 1033-1040

  • Cancer cells often become unresponsive to multiple types of therapy. It emerges that these ‘cross-resistant’ tumour cells release lipids that reprogram cells called monocytes to stop them from activating tumour-targeting T cells.

    • Anthony C. Buzzai
    • Thomas Tüting
    News & Views
    Nature
    Volume: 637, P: 549-551

  • A transplantable mouse model of persistent cutaneous melanoma shows that immune-mediated tumour suppression can result in a state of melanoma–immune equilibrium, and that tissue-resident memory T cells are essential drivers of this equilibrium state.

    • Simone L. Park
    • Anthony Buzzai
    • Thomas Gebhardt
    Research
    Nature
    Volume: 565, P: 366-371