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Showing 1–12 of 12 results
Advanced filters: Author: Anthony J. Sadler Clear advanced filters

  • The importance of the post-translational modification by acetylation in regulating protein function is not fully understood. Here, the authors show that acetylation of the transcriptional factor PLZF promotes the assembly of a repressor complex that limits the inflammatory response mediated by NF-κB.

    • Anthony J. Sadler
    • Bandar A. Suliman
    • Dakang Xu
    Research
    Nature Communications
    Volume: 6, P: 1-11

  • Inflammasomes are multiprotein complexes, including the protein ASC, that assemble in response to inflammatory stimulation. Here the authors characterise the regulation of ASC during inflammasome formation and show the involvement of SUMOylation and zinc-finger and BTB domain-containing protein 16 (ZBTB16).

    • Danfeng Dong
    • Yuzhang Du
    • Dakang Xu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The resilience of a global sample of ecosystems to an increase in drought conditions is assessed, comparing data from the early twenty-first with the late twentieth century; results indicate a cross-ecosystem capacity for tolerating low precipitation and responding to high precipitation during recent warm drought and yet suggest a threshold to resilience with prolonged warm drought.

    • Guillermo E. Ponce-Campos
    • M. Susan Moran
    • Patrick J. Starks
    Research
    Nature
    Volume: 494, P: 349-352

  • The metabolic environment of tumours has wide-ranging effects on the anti-tumour immune response and the outcome of immune therapy. Authors show here that the purine metabolite inosine enhances tumour immunogenicity and thus immune checkpoint blockade therapy response by inhibiting the ubiquitin-activating enzyme UBA6 in tumour cells.

    • Lei Zhang
    • Li Jiang
    • Baokun He
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The use of earth-abundant metals in catalysis is a prerequisite for the development of sustainable synthetic chemical processes for the future. Now, biomass-derived chemicals can be used in an efficient iron-catalysed reaction to make complex spirocycles. The resulting products contain two asymmetric centres that are furnished in high stereoselectivity.

    • Kirsty Adams
    • Anthony K. Ball
    • Joseph B. Sweeney
    Research
    Nature Chemistry
    Volume: 9, P: 396-401

  • With recent and improved understanding of how nuclear and electronic degrees of freedom can interact with each other comes the opportunity to directly control electronic processes. Now it has been shown that ultrafast vibrational excitation can direct light-induced intramolecular electron transfer along a specific path.

    • Milan Delor
    • Stuart A. Archer
    • Julia A. Weinstein
    Research
    Nature Chemistry
    Volume: 9, P: 1099-1104

  • Type I interferons (IFNs) provide the first line of defence against viral infection. As discussed in this Review, the IFN-induced antiviral effector proteins, such as ISG15, Mx proteins, ribonuclease L and protein kinase R, are important components of this response.

    • Anthony J. Sadler
    • Bryan R. G. Williams
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 559-568