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Showing 1–4 of 4 results
Advanced filters: Author: Anthony J. Trimboli Clear advanced filters

  • The tumour microenvironment has an important role in tumorigenesis. Here, the genetic inactivation of Pten in stromal fibroblasts of mouse mammary glands is shown to accelerate the initiation, progression and malignant transformation of mammary epithelial tumours. The data presented suggest that the Pten–Ets2 axis — Ets2 being a transcription factor activated by the loss of Pten — is a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours.

    • Anthony J. Trimboli
    • Carmen Z. Cantemir-Stone
    • Gustavo Leone
    Research
    Nature
    Volume: 461, P: 1084-1091

  • Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchnic mesenchyme as the tissue of origin for CAFs.

    • Lu Han
    • Yongxia Wu
    • Gustavo Leone
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia.

    • Gina M. Sizemore
    • Subhasree Balakrishnan
    • Michael C. Ostrowski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14